| Item Type | Name |
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Concept
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Cell Line, Transformed
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Concept
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Cell Line, Tumor
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Concept
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Cell Line
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Academic Article
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Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.
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Academic Article
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Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src.
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Academic Article
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Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells.
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Academic Article
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Insulin-degrading enzyme does not require peroxisomal localization for insulin degradation.
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Academic Article
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Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth.
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Academic Article
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ERK7 is an autoactivated member of the MAPK family.
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Academic Article
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Regulation of insulin degradation: expression of an evolutionarily conserved insulin-degrading enzyme increases degradation via an intracellular pathway.
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Academic Article
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ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway.
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Academic Article
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Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.
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Academic Article
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Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
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Academic Article
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tRNA over-expression in breast cancer and functional consequences.
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Academic Article
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Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin.
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Academic Article
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Anthrax edema factor potency depends on mode of cell entry.
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Academic Article
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Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.
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Academic Article
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Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
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Academic Article
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Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
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Academic Article
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Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
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Academic Article
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Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.
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Academic Article
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Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.
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Academic Article
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Anti-tumor effects of an engineered "killer" transfer RNA.
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Academic Article
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Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
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Academic Article
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The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
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Academic Article
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Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
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Academic Article
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A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
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Academic Article
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Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expression.
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Academic Article
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Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.
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Academic Article
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Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor.
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Academic Article
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Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin.
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Academic Article
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Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts.
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Academic Article
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Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe.
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Academic Article
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Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
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Academic Article
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Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
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Academic Article
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Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
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Academic Article
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Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
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Academic Article
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Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells.
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Academic Article
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Activation of mitogen-activated protein kinase by epidermal growth factor in hippocampal neurons and neuronal cell lines.
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Academic Article
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Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster.
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Academic Article
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Growth state-dependent regulation of protein kinase C in normal and transformed murine cells.
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Academic Article
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Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking.
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Academic Article
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Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells.
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Academic Article
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Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
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Academic Article
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Induction of epidermal growth factor receptor gene transcription by transforming growth factor beta 1: association with loss of protein binding to a negative regulatory element.
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Academic Article
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Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
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Academic Article
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Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
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Academic Article
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Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
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Academic Article
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Insulin gene expression in immortalized rat hippocampal and pheochromocytoma-12 cell lines.
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Academic Article
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Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
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Academic Article
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Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
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Academic Article
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A proline- and glutamine-rich protein promotes apoptosis in neuronal cells.
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Academic Article
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Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation.
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Academic Article
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Cytoplasmic/nuclear localization of tuberin in different cell lines.
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Academic Article
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mTOR phosphorylated at S2448 binds to raptor and rictor.
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Academic Article
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Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.
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Academic Article
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Tuberin negatively affects BCL-2's cell survival function.
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Academic Article
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Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR.
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Academic Article
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Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
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Academic Article
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Tuberin, p27 and mTOR in different cells.
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Academic Article
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The TSC1 gene product, hamartin, negatively regulates cell proliferation.
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Academic Article
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Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
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Academic Article
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HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
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Academic Article
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Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
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Academic Article
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Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.
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Academic Article
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Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
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Academic Article
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Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells.
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Academic Article
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RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
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Academic Article
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An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
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Academic Article
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Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
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Academic Article
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Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.
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Academic Article
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Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
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Academic Article
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A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
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Academic Article
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RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
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Academic Article
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Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
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Academic Article
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Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
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Academic Article
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Interaction of tRNA with MEK2 in pancreatic cancer cells.
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Academic Article
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Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
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Academic Article
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Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
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Academic Article
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Limited inhibition of multiple nodes in a driver network blocks metastasis.
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Grant
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Modulation of Head and Neck Cancer by Protein Kinase C
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